在这部飞天小女警Z儿童/动作/科幻片中,一日，致力于研究化学X神秘物质的ユートニウム博士跟助手同时也是他儿子肯发现了一种新物质Z。这种物质发射出一道白光跟一道黑光，在东京城中放出。 这道白光打到了初中一年级生赤堤ももこ、豪徳寺みやこ、松原かおる这3个女孩身上，于是，3个飞天小女警诞生了！！ 与此同时，那道黑光打到了东京动物园里。一座猴子山上的猴子变成了飞天小女警们的宿敌。小女警们将怎样保卫这座城市呢？……
Based on the American cartoon, "The Powerpuff Girls", Professor Utonium and his son Ken are studying the strange Chemical X. When a mochi cake falls into the formula, it changes into Chemical Z. Ken fires a ray of Chemical Z at a glacier in Tokyo Bay, however that causes strange black and white lights to scatter. The black lights turn its victims into monsters, with emphasis on a black light hitting a zoo monkey and transforming him into Mojo Jojo. The white lights, however, aim at three normal girls, Momoko, Miyako, and Kaoru. This gives them the power to transform into superheroes, the Powerpuff Girls Z!
